Rapid Calm

Rapid Calm delivers rapid-acting support for occasional anxiety in less than one hour. Zembrin®, a patented extract of Sceletium tortuosum, has been clinically studied and shown to help moderate general feelings of stress and occasional anxiety. In a clinical trial, a single dose of 25 mg Zembrin® reduced perceived levels of occasional anxiety and its physical symptoms, such as elevated heart rate, in healthy volunteers, within 1 hour.1 In another randomized clinical trial, a single 25 mg dose of Zembrin® moderated fear responsivity and activation of the brain's amygdala, assessed using pharmaco-fMRI.2 The amygdala is a part of the brain that reacts to threats and communicates with the rest of the related areas of the brain to regulate feelings of fear and nervousness in threatening situations. In vitro evidence indicates that Zembrin® might work by inhibiting serotonin reuptake, prolonging the effects of serotonin.3 Serotonin is a neurotransmitter involved in relaxation and mood. L-theanine complements Zembrin® by supporting a relaxed and alert mental state.4 Vitamin B6 is a cofactor in the biosynthesis of serotonin.5 This formula is ideal for as-needed relief from occasional everyday stressors.‡ References Reay J, Wetherell MA, Morton E. Hum Psychopharmacol. 2020 Nov;35(6):1-7. doi: 10.1002/hup.2753. Epub 2020 Aug 6. PMID: 32761980. Terburg D, Syal S, Rosenberger LA, et al. Neuropsychopharmacology. 2013 Dec;38(13):2708-16. doi: 10.1038/npp.2013.183. Harvey AL, Young LC, Viljoen AM, Gericke NP. J Ethnopharmacol. 2011 Oct 11;137(3):1124-9. doi: 10.1016/j.jep.2011.07.035. Hidese S, Ogawa S, Ota M, et al. Nutrients. 2019 Oct 3;11(10):2362. doi: 10.3390/nu11102362. Blau N, Pearson TS, Kurian MA, et al. 2023 Oct 12. In: Adam MP, Feldman J, Mirzaa GM, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2024.